Oncostatin M induces tumorigenic properties in non-transformed human prostate epithelial cells, in part through activation of signal transducer and activator of transcription 3 (STAT3)
2018 (engelsk)Inngår i: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 498, nr 4, s. 769-774Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
Prostate cancer is one of the most common types of cancer in men in Western countries. Chronic inflammation in the prostate, regulated by a complex network of factors including inflammatory cytokines, is one of the established risk factors for development of prostate cancer. Interleukin-6 (IL-6) is a well-known promoter of inflammation-induced carcinogenesis and disease progression in prostate cancer. Presence in the prostate and possible roles in tumor development by other members of the IL-6 family of cytokines have, however, been less studied. Here we show that the IL-6-type cytokine oncostatin M (OSM) indeed induce cellular properties associated with tumorigenesis and disease progression in non-transformed human prostate epithelial cells, including morphological changes, epithelial-to-mesenchymal transition (EMT), enhanced migration and pro-invasive growth patterns. The effects by OSM were partly mediated by activation of signal transducer and activator of transcription 3 (STAT3), a transcription factor established as driver of cancer progression and treatment resistance in numerous types of cancer. The findings presented here further consolidate IL-6-type cytokines and STAT3 as promising future treatment targets for prostate cancer.
sted, utgiver, år, opplag, sider
Elsevier, 2018. Vol. 498, nr 4, s. 769-774
Emneord [en]
Prostate cancer, Oncostatin M, EMT, STAT3
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-138595DOI: 10.1016/j.bbrc.2018.03.056ISI: 000430158200011PubMedID: 29526757OAI: oai:DiVA.org:umu-138595DiVA, id: diva2:2240
2018-06-142018-06-142018-06-14bibliografisk kontrollert