Elongator-a tRNA modifying complex that promotes efficient translational decoding
2018 (English)In: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, ISSN 1874-9399, E-ISSN 1876-4320, Vol. 1861, no 4, p. 401-408Article in journal (Refereed) Published
Abstract [en]
Naturally occurring modifications of the nucleosides in the anticodon region of tRNAs influence their translational decoding properties. Uridines present at the wobble position in eukaryotic cytoplasmic tRNAs often contain a 5-carbamoylmethyl (ncm(5)) or 5-methoxycarbonylmethyl (mcm(5)) side-chain and sometimes also a 2-thio or 2'-O-methyl group. The first step in the formation of the ncm5 and mcm5 side-chains requires the conserved six-subunit Elongator complex. Although Elongator has been implicated in several different cellular processes, accumulating evidence suggests that its primary, and possibly only, cellular function is to promote modification of tRNAs. In this review, we discuss the biosynthesis and function of modified wobble uridines in eukaryotic cytoplasmic tRNAs, focusing on the in vivo role of Elongator-dependent modifications in Saccharomyces cerevisiae. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena.
Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 1861, no 4, p. 401-408
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-138605DOI: 10.1016/j.bbagrm.2017.11.006ISI: 000430523900013PubMedID: 29170010OAI: oai:DiVA.org:umu-138605DiVA, id: diva2:2123
Funder
Carl Tryggers foundation , CTS13:206Åke Wiberg Foundation, M14-0207Swedish Research Council, 621-2016-039492018-06-132018-06-132018-06-13Bibliographically approved